High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu, +7

Journal of Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseAmyloid PlaquesDementia +13

Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

Jorge J. Palop, Jeannie Chin, Erik D. Roberson, +10

Neuron

Compensatory RemodelingAlzheimer's DiseaseBrain FunctionMedicineDementia +9

Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Erik D. Roberson, Brian Halabisky, Jong W. Yoo, +10

Journal of Neuroscience

Synaptic TransmissionNeurochemical BiomarkersMultiple Mouse ModelsTau LevelsSynaptic Signaling +21

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Tony Wyss‐Coray, Carol Lin, Fengrong Yan, +5

Nature Medicine

InflammationNeurodegenerative DiseasesMedicineImmunologyDegenerative Pathology +5

Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease

Sarah Mueller-Steiner, Yungui Zhou, Hideaki Arai, +8

Neuron

InflammationAlzheimer's DiseaseCathepsin BMedicineAutophagy +12

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

Moustapha Cissé, Brian Halabisky, Julie A. Harris, +10

Nature

Alzheimer ModelAlzheimer's DiseaseMolecular NeuroscienceDementiaNeurochemical Biomarkers +5

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

Walter J. Brecht, Faith M. Harris, Shengjun Chang, +9

Journal of Neuroscience

Cell DeathTransgenic MiceSocial SciencesNeuroinflammationAlzheimer's Disease +22

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

Julie A. Harris, Nino Devidze, Laure Verret, +10

Neuron

Synaptic PlasticityNeurodegenerative DiseasesSynaptic NeuroscienceSynaptic TransmissionNeurology +7

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Anna G. Orr, Edward C. Hsiao, Max Wang, +12

Nature Neuroscience

Molecular PhysiologyMemoryRegulate MemoryNeuroscienceMolecular Neurobiology +1

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

Binggui Sun, Brian Halabisky, Yungui Zhou, +4

Cell stem cell

Synaptic PlasticityDevelopmental BiologyAlzheimer's DiseaseDementiaAnimal Model +8