Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Sang-Won Min, Seo-Hyun Cho, Yungui Zhou, +11

Neuron

BiochemistryNatural SciencesMolecular BiologyDegenerative PathologyTau Inhibits +2

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Jennifer Chen, Yungui Zhou, Sarah Mueller-Steiner, +5

Journal of Biological Chemistry

ImmunologyImmune RegulationCell DeathOxidative StressNeuroinflammation +17

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Sang‐Won Min, Xu Chen, Tara E. Tracy, +19

Nature Medicine

Neurodegenerative DiseasesAlzheimer's DiseaseDementiaDegenerative DiseaseDegenerative Pathology +7

Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease

Sarah Mueller-Steiner, Yungui Zhou, Hideaki Arai, +8

Neuron

InflammationAlzheimer's DiseaseCathepsin BMedicineAutophagy +12

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Rene O. Sanchez-Mejia, John W. Newman, Sandy Toh, +10

Nature Neuroscience

Alzheimer's DiseaseMolecular NeuroscienceMedicineDementiaPhospholipase A2 Reduction +10

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesús Madero‐Pérez, Danielle L. Swaney, +27

Cell

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Chao Wang, Li Fan, Rabia R. Khawaja, +16

Nature Communications

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

Seo-Hyun Cho, Jason Chen, Faten A. Sayed, +11

Journal of Neuroscience

AgingImmunologyBiogerontologyBrain AgesSirt1 Deficiency +14

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

Seo-Hyun Cho, Binggui Sun, Yungui Zhou, +5

Journal of Biological Chemistry

Plaque-independent Cognitive DeficitsImmunologyNeurochemical BiomarkersAberrant Microglial ActivationSynaptic Signaling +25

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tara E. Tracy, Peter Sohn, Sakura Minami, +12

Neuron

Neurodegenerative DiseasesSynaptic PlasticitySignal TransductionAlzheimer's DiseaseSynaptic Transmission +8