Thiopurine<i>S</i>-Methyltransferase Pharmacogenetics in a Large-Scale Healthy Italian–Caucasian Population: Differences in Enzyme Activity

Abstract

The data obtained in this study show that genetic factors seem to be the major aspect in TPMT phenotype variability in adults, whilst, in children, other physiological factors should be taken into consideration when assessing the TPMT phenotype, such as age and gender.