Concepedia

Tpmt Genotype

TPMT Genotype is a genetic polymorphism profile of the thiopurine S-methyltransferase gene that determines individual enzymatic activity levels and influences the metabolism of thiopurine drugs in pediatric pharmacogenomic applications.

392

Publications

23.2K

Citations

2.2K

Authors

710

Institutions

Publications per year

2017–2026

58

Variants

Thiopurine S-methyltransferase Genotype

Parents

Publications

392

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

, , +13

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on <i><scp>TPMT</scp></i> and <i><scp>NUDT</scp>15</i> Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl‐Carrillo et al. · Clinical Pharmacology & Therapeutics · 2018 · 662 citations · Full text

, , +17

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

Jean‐Frédéric Colombel, Nicolas Ferrari, Hervé Debuysère et al. · Gastroenterology · 2000 · 615 citations · Full text

, , +17

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

Mary V. Relling, E E Gardner, William J. Sandborn et al. · Clinical Pharmacology & Therapeutics · 2011 · 573 citations · Full text

, , +17

Comprehensive analysis of thiopurine S-methyltransferase phenotype–genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

Elke Schaeffeler, Christine Fischer, D. Brockmeier et al. · Pharmacogenetics · 2004 · 420 citations

, , +14

1–5 of 392

Authors

2.2K

  1. WE
    William E. Evans

    St. Jude Children's Research Hospital, United States

    19 publications · 3.5K citations

    16

    h-index

  2. RM
    Richard M. Weinshilboum

    Mayo Clinic, United States

    15 publications · 2K citations

    14

    h-index

  3. MV
    Mary V. Relling

    St. Jude Children's Research Hospital, United States

    13 publications · 2.4K citations

    12

    h-index

  4. SL
    Soo‐Youn Lee

    Samsung Medical Center, South Korea

    11 publications · 336 citations

    11

    h-index

  5. KS
    Kjeld Schmiegelow

    Rigshospitalet, Denmark

    11 publications · 1.5K citations

    11

    h-index

1–5 of 2.2K

Institutions

710

  1. St. Jude Children's Research Hospital

    Memphis, United States

    21 h-index

    127 publications

    20K citations

  2. Mayo Clinic

    Rochester, United States

    17 h-index

    46 publications

    4.3K citations

  3. Linköping University

    Linköping, Sweden

    17 h-index

    45 publications

    2.6K citations

  4. Sungkyunkwan University

    Seoul, South Korea

    11 h-index

    66 publications

    2K citations

  5. Samsung Medical Center

    Seoul, South Korea

    11 h-index

    73 publications

    2.3K citations

  6. National University of Singapore

    Singapore, Singapore

    10 h-index

    15 publications

    1.4K citations

  7. Sun Yat-sen University

    Guangzhou, China

    9 h-index

    57 publications

    2.3K citations

  8. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    9 h-index

    31 publications

    5.9K citations

1–8 of 710

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 20 publications · 2.9K citations

    18

    h-index

  2. Pharmacogenetics

    16 publications · 2.3K citations

    16

    h-index

  3. British Journal of Clinical Pharmacology

    BJCP · 15 publications · 972 citations

    15

    h-index

  4. PubMed

    Repository · 22 publications · 1.7K citations

    14

    h-index

  5. Therapeutic Drug Monitoring

    14 publications · 665 citations

    13

    h-index

1–5