Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

Veterinary Medicine, Genetics, Pharmacology +13

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

Charles R. Yates, Eugene Y. Krynetski, Thrina Loennechen et al. · Annals of Internal Medicine · 1997 · 763 citations

Life Sciences, Genetics, Pharmacology +13

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

Daniel H. Present, Stephen J. Meltzer, Michael P. Krumholz et al. · Annals of Internal Medicine · 1989 · 737 citations

Medicine, Pharmacology, Pharmacotherapy +11

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

Lynne Lennard, J S Lilleyman, Jon Van Loon et al. · The Lancet · 1990 · 659 citations

Life Sciences, Genetics, Pediatrics +9

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

William Connell, MA Kamm, J K Ritchie et al. · Gut · 1993 · 516 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15