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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison, Pritom Shah, Martin R. Johnson, Graham G. A. Inglis, Geoffrey D. Clarke, Robin A.J. Smith, Davina Humphreys, Christopher R. Molloy,

Bioorganic & Medicinal Chemistry Letters · 2001 · 46 citations · 8 references

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References

8

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Manuel A. Navia, Brian M. McKeever, James P. Springer et al. · Proceedings of the National Academy of Sciences · 1989 · 237 citations

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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

P E Finke, S. K. Shah, D. Fletcher et al. · Journal of Medicinal Chemistry · 1995 · 89 citations · Full text

, , +9

Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase

Chris A. Veale, Peter R Bernstein, Claudia Bohnert et al. · Journal of Medicinal Chemistry · 1997 · 70 citations · Full text

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Novel Natural Product 5,5-<i>trans</i>-Lactone Inhibitors of Human α-Thrombin:  Mechanism of Action and Structural Studies

Malcolm Weir, Susanne S. Bethell, Anne Cleasby et al. · Biochemistry · 1998 · 41 citations

, , +16

A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure <i>trans</i>-5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles (Pyrrolidine-<i>trans</i>-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology

Simon J. F. Macdonald, Geoffrey D. Clarke, Michael D. Dowle et al. · The Journal of Organic Chemistry · 1999 · 36 citations

, , +12