Lee A. Harrison

The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor

Jonathan T. Seal, Stephen J. Atkinson, Helen Aylott et al. · Journal of Medicinal Chemistry · 2020 · 63 citations · Full text

Discovery of Further Pyrrolidine <i>trans</i>-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Journal of Medicinal Chemistry · 2002 · 54 citations · Full text

Crystal Structure, Pharmaceutical Science, Hne Complexed +16

A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor

Peter Murray, Lee A. Harrison, Martin R. Johnson et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 49 citations

Medicinal Chemistry, Novel Series, Biochemistry +12

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 46 citations · Full text

Inflammation, Granulocyte, Development Candidate +7

A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure <i>trans</i>-5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles (Pyrrolidine-<i>trans</i>-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology

Simon J. F. Macdonald, Geoffrey D. Clarke, Michael D. Dowle et al. · The Journal of Organic Chemistry · 1999 · 36 citations