Simon J. F. Macdonald

The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace et al. · MedChemComm · 2012 · 178 citations

Pharmacy, Chemistry, Pharmacology +6

Asymmetric Epoxidation of Chalcones with Chirally Modified Lithium and Magnesium <i>tert</i> ‐Butyl Peroxides

Catherine L. Elston, Richard F. W. Jackson, Simon J. F. Macdonald et al. · Angewandte Chemie International Edition in English · 1997 · 136 citations

Natural Sciences, Chemistry, Catalysis +11

Lead Optimization Using Matched Molecular Pairs: Inclusion of Contextual Information for Enhanced Prediction of hERG Inhibition, Solubility, and Lipophilicity

George Papadatos, M. Alkarouri, Valerie J. Gillet et al. · Journal of Chemical Information and Modeling · 2010 · 130 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Alison E. John, Rebecca H. Graves, Kwok‐Tao Pun et al. · Nature Communications · 2020 · 124 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Increasing small molecule drug developability in sub-optimal chemical space

Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace et al. · MedChemComm · 2013 · 102 citations

Pharmacy, Chemistry, Medicinal Chemistry +17