Christopher R. Molloy

Discovery of Further Pyrrolidine <i>trans</i>-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Journal of Medicinal Chemistry · 2002 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

6,6′-Bis(2-hydroxyphenyl)-2,2′-bipyridine manganese(III) complexes: A novel series of superoxide dismutase and catalase mimetics

Gerard M.P. Giblin, Philip C Box, Ian B. Campbell et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 26 citations

Natural Sciences, Biochemistry, Chemistry +14

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 14 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8