Davina Humphreys

Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series

Mike D. Barker, Margaret Clackers, Royston C. B. Copley et al. · Journal of Medicinal Chemistry · 2006 · 77 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of Further Pyrrolidine <i>trans</i>-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Journal of Medicinal Chemistry · 2002 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method

Mike D. Barker, Margaret Clackers, Derek A. Demaine et al. · Journal of Medicinal Chemistry · 2005 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

Keith Biggadike, Mohamed Boudjelal, Margaret Clackers et al. · Journal of Medicinal Chemistry · 2007 · 41 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13