Margaret Clackers

Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series

Mike D. Barker, Margaret Clackers, Royston C. B. Copley et al. · Journal of Medicinal Chemistry · 2006 · 77 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Tetrahydronaphthalene-benzoxazine Glucocorticoid Receptor +15

Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method

Mike D. Barker, Margaret Clackers, Derek A. Demaine et al. · Journal of Medicinal Chemistry · 2005 · 44 citations · Full text

Molecular Docking, Medicinal Chemistry, G Protein-coupled Receptor +10

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

Keith Biggadike, Mohamed Boudjelal, Margaret Clackers et al. · Journal of Medicinal Chemistry · 2007 · 40 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Mmtv Agonism +14

Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics

Margaret Clackers, Diane M. Coe, Derek A. Demaine et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 30 citations · Full text

Molecular Pharmacology, Bioorganic Chemistry, Biochemistry +11

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists

Keith Biggadike, Matilde Caivano, Margaret Clackers et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations · Full text

Functional Selectivity, Medicine, Receptor (Biochemistry) +4