5-Benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

Jennifer L. Stamos, Mark X. Sliwkowski, Charles Eigenbrot · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Alexander J. Bridges, Hairong Zhou, Donna R. Cody et al. · Journal of Medicinal Chemistry · 1996 · 322 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines

Tohru Fukuyama, Mui Cheung, Chung-Kuang Jow et al. · Tetrahedron Letters · 1997 · 285 citations

Natural Sciences, Chemistry, Organic Chemistry +1

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Allan Wissner, Dan M. Berger, Diane H. Boschelli et al. · Journal of Medicinal Chemistry · 2000 · 209 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors:  4-(Phenylamino)pyrazolo[3,4-<i>d</i>]pyrimidines

Peter Traxler, Guido Bold, Joerg Frei et al. · Journal of Medicinal Chemistry · 1997 · 205 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17