Concepedia

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

Dearg S. Brown, John G. Cumming, Paul A. Bethel, Jonathan Finlayson, S. Gerhardt, Ian A. Nash, Richard A. Pauptit, Kurt G. Pike, A. C. REID, Wendy L. Snelson,

Bioorganic & Medicinal Chemistry Letters · 2012 · 11 citations · 13 references

DOIFull text

Open access

Concepts

References

13

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

, , +14

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Christopher Pargellis, Liang Tong, Laurie Churchill et al. · Nature Structural Biology · 2002 · 834 citations · Full text

, , +15

p38 MAP kinase inhibitors: many are made, but few are chosen.

Celia Dominguez, David Powers, Nuria Tamayo · PubMed · 2005 · 166 citations

, , +14

Approaches to Assessment, Testing Decisions, and Analytical Determination of Genotoxic Impurities in Drug Substances

Duane A. Pierson, Bernard A. Olsen, David K. Robbins et al. · Organic Process Research & Development · 2008 · 106 citations

, , +16

Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase

Jane E. Sullivan, Geoffrey A. Holdgate, Douglas A. Campbell et al. · Biochemistry · 2005 · 90 citations

, , +16