A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell, +15

Nature

InflammationCytokineSignal TransductionSignaling PathwayMolecular Pathway +11

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

Timothy F. Gallagher, George Seibel, Shouki Kassis, +20

Bioorganic & Medicinal Chemistry

InflammationCytokineReductive StressSignal TransductionCell Regulation +13

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

Peter R. Young, Peter McDonnell, Damien J. Dunnington, +3

Inflammation Research

InflammationTnf ProductionCytokineAnti-inflammatoryBiochemistry +6

1-Substituted 4-Aryl-5-pyridinylimidazoles:  A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

Jeffrey C. Boehm, Juanita M. Smietana, Margaret E. Sorenson, +12

Journal of Medicinal Chemistry

Aa Rat ModelLipid PeroxidationImmunologyCell DeathPharmacotherapy +19

A modified assay for interleukin-1 (IL-1)

P L Simon, Jeffrey T. Laydon, John C. Lee

Journal of Immunological Methods

InflammationCytokineImmunologyImmune RegulationModified Assay +2

Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNFα processing

Michael J. DiMartino, Christine Wolff, Whitney A. High, +9

Inflammation Research

Inhibitory ActivityTnfα ProcessingAnti-inflammatoryBiochemistryMedicine +6

Effect of a Human Immunodeficiency Virus Protease Inhibitor on Human Monocyte Function

Peter J. Bugelski, Johanne Kaplan, Timothy K. Hart, +5

AIDS Research and Human Retroviruses

Effect of SK&F 86002 on cytokine production by human monocytes

J. C. Lee, L Rebar, Jeffrey T. Laydon

Inflammation Research

InflammationCytokineGranulocyteImmune Cell DevelopmentImmunology +7

Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo

Don E. Griswold, Leonard M. Hillegass, J. O'Leary-Bartus, +3

Journal of Immunological Methods

InflammationHuman Cytokine ProductionPharmacological AgentsCytokineAllergy +8

Amphibian Melanophore Technology as a Functional Screen for Antagonists of G-Protein Coupled 7-Transmembrane Receptors

Mark Nuttall, John C. Lee, Paul R. Murdock, +11

SLAS DISCOVERY