George Seibel

AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules

David A. Pearlman, David A. Case, James W. Caldwell et al. · Computer Physics Communications · 1995 · 3.1K citations

Natural Sciences, Chemistry, Physics +17

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

Peter R. Young, Megan M. McLaughlin, Sanjay Kumar et al. · Journal of Biological Chemistry · 1997 · 573 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure

Renée L. DesJarlais, Robert P. Sheridan, George Seibel et al. · Journal of Medicinal Chemistry · 1988 · 404 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

Renée L. DesJarlais, George Seibel, Irwin D. Kuntz et al. · Proceedings of the National Academy of Sciences · 1990 · 254 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

Timothy F. Gallagher, George Seibel, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry · 1997 · 218 citations

Life Sciences, Immunology, Molecular Biology +14