The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Stephen T. Durant, Li Zheng, Yingchun Wang, +34

Science Advances

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Kurt G. Pike, Karine Malagu, Marc Hummersone, +7

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicinal ChemistryDrug TargetBiochemistryMedicine +10

Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes, +18

Molecular Cancer Therapeutics

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Sylvie M. Guichard, Jon Curwen, Teeru Bihani, +15

Molecular Cancer Therapeutics

Breast OncologyChemoprevention StrategyPharmacotherapyMtorc1 ComplexTumor Biology +16

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2<i>H</i>-pyran-4-yl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]quinolin-2-one)

Kurt G. Pike, Bernard Barlaam, Elaine Cadogan, +25

Journal of Medicinal Chemistry

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Bernard Barlaam, Robert Casella, Justin Cidado, +38

Journal of Medicinal Chemistry

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett, +9

Bioorganic & Medicinal Chemistry Letters

MedicineDrug DiscoveryGlycobiologySoluble Glucokinase ActivatorVivo Efficacy +4

Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

Gareth Coope, A M Atkinson, C Allott, +7

British Journal of Pharmacology

Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Sébastien L. Degorce, Bernard Barlaam, Elaine Cadogan, +11

Journal of Medicinal Chemistry

Bioorganic ChemistryMolecular BiologyPharmacotherapyPharmaceutical ChemistrySelective Atm Inhibitors +16

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of <i>MLL</i> -rearranged AML

Isabel Morgado-Palacin, Amanda Day, Matilde Murga, +16

Science Signaling