Concepedia

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Kurt G. Pike, Karine Malagu, Marc Hummersone, Keith Menear, Heather M. E. Duggan, Sylvie Gomez, Niall M.B. Martin, Linette Ruston, Sarah L. Pass, Martin Pass

Bioorganic & Medicinal Chemistry Letters · 2013 · 206 citations · 15 references

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15

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature · 1994 · 2.1K citations

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RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

David M. Sabatini, Hediye Erdjument‐Bromage, Mary Lui et al. · Cell · 1994 · 1.5K citations

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Diane C. Fingar, Sofie R. Salama, Christina Tsou et al. · Genes & Development · 2002 · 1.1K citations · Full text

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mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

Diane C. Fingar, Celeste Richardson, Andrew R. Tee et al. · Molecular and Cellular Biology · 2003 · 873 citations · Full text

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Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition

Shi-Yong Sun, Laura M. Rosenberg, Xuerong Wang et al. · Cancer Research · 2005 · 808 citations

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