Linette Ruston

Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

Andrew G. Leach, Huw Jones, David A. Cosgrove et al. · Journal of Medicinal Chemistry · 2006 · 283 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Kurt G. Pike, Karine Malagu, Marc Hummersone et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 206 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Species differences in drug plasma protein binding

Nicola Colclough, Linette Ruston, J. Matthew Wood et al. · MedChemComm · 2014 · 68 citations

Pharmacy, Pharmaceutics, Pharmacology +9

Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Qibin Su, Erica Banks, Geraldine Bebernitz et al. · Journal of Medicinal Chemistry · 2020 · 60 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

Amais Ahmad, Xavier Pépin, Leon Aarons et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2020 · 40 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16