The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

Michael Hedvat, Dennis Huszar, Andreas Herrmann, +23

Cancer Cell

Tumor BiologySignaling PathwaySolid TumorsMedicineReceptor Tyrosine Kinase +6

Discovery of 5-Chloro-<i>N</i>²-[(1<i>S</i>)-1-(5-fluoropyrimidin-2-yl)ethyl]-<i>N</i>⁴-(5-methyl-1<i>H</i>-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Stephanos Ioannidis, Michelle L. Lamb, Tao Wang, +18

Journal of Medicinal Chemistry

Novel InhibitorPotent Jak2 InhibitorChemical BiologyPharmaceutical ChemistryMyeloid Neoplasia +22

Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2

Joseph M. Gozgit, Geraldine Bebernitz, Pankaj Patil, +9

Journal of Biological Chemistry

Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites

E Z Baum, Geraldine Bebernitz, J D Hulmes, +3

Journal of Virology

Viral ReplicationImmunologyProteasomeMolecular BiologyPathology +15

Discovery of 1-Methyl-1<i>H</i>-imidazole Derivatives as Potent Jak2 Inhibitors

Qibin Su, Stephanos Ioannidis, Claudio Chuaqui, +14

Journal of Medicinal Chemistry

Compound 19APharmaceutical ChemistryTumor BiologyMedicinal ChemistryReceptor Tyrosine Kinase +16

Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Qibin Su, Erica Banks, Geraldine Bebernitz, +24

Journal of Medicinal Chemistry

Isolation of mutants of human immunodeficiency virus protease based on the toxicity of the enzyme in Escherichia coli.

E Z Baum, Geraldine Bebernitz, Y Gluzman

Proceedings of the National Academy of Sciences

Pol GeneBiochemistryMedicineNatural SciencesPathogenesis +12

Rapid methods for screening low molecular mass compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease

Marshall M. Siegel, Keiko Tabei, Geraldine Bebernitz, +1

Journal of Mass Spectrometry

Molecular BiologyCytomegalovirus ProteaseProtein PurificationBioanalysisAntiviral Drug Development +17

Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants

Thomas R. Jones, Lei Sun, Geraldine Bebernitz, +4

Journal of Virology

Viral ReplicationMolecular VirologyUl80 PolyproteinProteolytic ActivityMedicine +13

Purification, properties, and mutagenesis of poliovirus 3C protease

Ellen Z. Baum, Geraldine Bebernitz, Olga Palant, +2

Virology

Virus StructureViral ReplicationPathogenesisMolecular BiologyVirology +2