Sylvie Gomez

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 572 citations · Full text

Medicinal Chemistry, Polymerase Activation, Oral Bioavailability +15

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Kurt G. Pike, Karine Malagu, Marc Hummersone et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 204 citations · Full text

Molecular Docking, Medicinal Chemistry, Drug Target +12

Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase

Vincent M. Loh, Xiaoling Cockcroft, Krystyna J. Dillon et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 92 citations · Full text

Combinatorial Chemistry, Novel Series, Biochemistry +10

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Karine Malagu, Heather M. E. Duggan, Keith Menear et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 79 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +11

Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR

Keith Menear, Sylvie Gomez, Karine Malagu et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 55 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +10