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The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Combinatorial ChemistryMedicinal ChemistryDrug TargetBiochemistryNatural SciencesMedicineRational Drug DesignMechanism Of ActionSelective InhibitorsMtor KinaseChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery