Concepedia

Stereochemical Optimization

Stereochemical Optimization is a lead optimization strategy in medicinal chemistry that systematically varies and refines the stereochemical configuration of a lead compound to enhance target affinity, selectivity, and overall pharmacological profile while reducing off-target effects and liabilities.

4.7K

Publications

189.7K

Citations

17.1K

Authors

2.1K

Institutions

Publications per year

2017–2026

656

Parents

Children

Publications

4.7K

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

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Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis

Satoru Masamune, William Choy, John S. Petersen et al. · Angewandte Chemie International Edition in English · 1985 · 1.1K citations

, , +14

Thousands of chemical starting points for antimalarial lead identification

Francisco‐Javier Gamo, Laura M. Sanz, Jaume Vidal et al. · Nature · 2010 · 1K citations

, , +12

Stereoelectronic effects in organic chemistry

Geoffrey Hallas · Endeavour · 1984 · 968 citations

, , +10

Control of four stereocentres in a triple cascade organocatalytic reaction

Dieter Enders, Matthias R. M. Hüttl, Christoph Grondal et al. · Nature · 2006 · 907 citations

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1–5 of 4.7K

Authors

17.1K

  1. SH
    Stephen Hanessian

    Université de Montréal, Canada

    26 publications · 1.1K citations

    20

    h-index

  2. KN
    K. N. Houk

    University of California, Los Angeles, United States

    22 publications · 1.1K citations

    20

    h-index

  3. SJ
    Samuel J. Danishefsky

    Columbia University, United States

    21 publications · 1.3K citations

    18

    h-index

  4. EJ
    E. J. Corey

    Harvard University, United States

    19 publications · 1.1K citations

    17

    h-index

  5. JS
    J. S. Yadav

    Indian Institute of Chemical Technology, India

    26 publications · 673 citations

    17

    h-index

1–5 of 17.1K

Institutions

2.1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    38 h-index

    551 publications

    17.4K citations

  2. Harvard University

    Cambridge, United States

    35 h-index

    184 publications

    20.1K citations

  3. The University of Tokyo

    Tokyo, Japan

    30 h-index

    176 publications

    6.7K citations

  4. Chinese Academy of Sciences

    Beijing, China

    30 h-index

    289 publications

    12K citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    30 h-index

    531 publications

    22.3K citations

  6. Indian Institute of Chemical Technology

    Hyderabad, India

    28 h-index

    357 publications

    9.4K citations

  7. Shanghai Institute of Organic Chemistry

    Shanghai, China

    28 h-index

    140 publications

    6.8K citations

  8. Scripps Research Institute

    San Diego, United States

    25 h-index

    128 publications

    9.6K citations

1–8 of 2.1K

Venues

  1. Journal of the American Chemical Society

    JACS · 199 publications · 18.2K citations

    82

    h-index

  2. The Journal of Organic Chemistry

    JOC · 386 publications · 15.6K citations

    63

    h-index

  3. Organic Letters

    OL · 332 publications · 14.5K citations

    61

    h-index

  4. Tetrahedron Letters

    896 publications · 24.7K citations

    59

    h-index

  5. Angewandte Chemie International Edition

    108 publications · 7.6K citations

    55

    h-index

1–5