Heather M. E. Duggan

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Kurt G. Pike, Karine Malagu, Marc Hummersone et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 204 citations · Full text

Molecular Docking, Medicinal Chemistry, Drug Target +12

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Karine Malagu, Heather M. E. Duggan, Keith Menear et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 79 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +11

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype

Céline Cano, Olivier Barbeau, C. L. Bailey et al. · Journal of Medicinal Chemistry · 2010 · 45 citations

Chromen-4-one Chemotype, Target Enzyme, Drug Target +20

Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external β-turns

Heather M. E. Duggan, Peter B. Hitchcock, Douglas W. Young · Organic & Biomolecular Chemistry · 2005 · 27 citations