Jan Drzewiecki

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 586 citations · Full text

Medicine, Oncology, Pharmacology +16

Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase

Vincent M. Loh, Xiaoling Cockcroft, Krystyna J. Dillon et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 92 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +13

Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase

Xiaoling Cockcroft, Krystyna J. Dillon, Lesley Dixon et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 88 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +13

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Karine Malagu, Heather M. E. Duggan, Keith Menear et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase

Keith Menear, Claire Adcock, Francisco Cuenca Alonso et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 40 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +10