Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen, +41

Journal of Medicinal Chemistry

Drug TargetSolid TumorsMolecular BiologyCryptic PocketChemical Biology +18

Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

Maria Camila Almeida, Tamara Hew‐Butler, Renato Nery Soriano, +10

Journal of Neuroscience

Cutaneous Trpm8 ChannelsImmunologyTrpm8 ChannelsThermal TherapyExperimental Pharmacology +17

p38 MAP kinase inhibitors: many are made, but few are chosen.

Celia Dominguez, David Powers, Nuria Tamayo

PubMed

Drug TargetApoptosisImmunologyCell DeathPharmacotherapy +18

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1 H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

Sonya G. Lehto, Rami Tamir, Hong Deng, +18

Journal of Pharmacology and Experimental Therapeutics

Revised Structures for the Kinamycin Antibiotics: 5-Diazobenzo[b]fluorenes Rather Than Benzo[b]carbazole Cyanamides

Steven J. Gould, Nuria Tamayo, Chris R. Melville, +1

Journal of the American Chemical Society

Altmetric Attention ScoreAntimicrobial ChemotherapyHeterocycle ChemistryPharmaceutical ChemistryDrug Resistance +17

Palladium-catalyzed coupling of 2-bromonaphthoquinones with stannanes: a concise synthesis of antibiotics WS 5995 A and C and related compounds

Nuria Tamayo, Antonio M. Echavarren, M. C. PAREDES

The Journal of Organic Chemistry

Palladium-catalyzed CouplingEngineeringAltmetric Attention ScoreOrganic ChemistryAntimicrobial Chemotherapy +15

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

Nuria Tamayo, Hongyu Liao, Markian M. Stec, +9

Journal of Medicinal Chemistry

Pain MedicineTrpv1 AntagonistsNeuropathic PainMolecular PainPharmacotherapy +15

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Nobuko Nishimura, Aaron Siegmund, Longbin Liu, +19

Journal of Medicinal Chemistry

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Nuria Tamayo, Yunxin Bo, Vijay Gore, +13

Journal of Medicinal Chemistry

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

Marc Payton, Brian Belmontes, Kelly Hanestad, +26

Nature Cancer