New thiazole carboxamides as potent inhibitors of Akt kinases

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt‐3

Stefan Masure, Burkhard Haefner, Jan‐Jaap Wesselink et al. · European Journal of Biochemistry · 1999 · 159 citations · Full text

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3<i>S</i>)-3-piperidinylmethyl]oxy}-1<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Dirk A. Heerding, Nelson Rhodes, Jack D. Leber et al. · Journal of Medicinal Chemistry · 2008 · 154 citations · Full text

Cell Death, Akt Kinase, Molecular Pharmacology +20

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

Gordon Saxty, Steven J. Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2007 · 138 citations · Full text

Molecular Docking, Medicinal Chemistry, Drug Target +14

Identification of 4-(4-Aminopiperidin-1-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration

John Caldwell, Thomas G. Davies, Alastair Donald et al. · Journal of Medicinal Chemistry · 2008 · 99 citations · Full text

Discovery of 4-Amino-1-(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

Tatiana McHardy, John Caldwell, Kwai-Ming J. Cheung et al. · Journal of Medicinal Chemistry · 2010 · 83 citations · Full text

Drug Target, Related Kinase Pka, Pharmacotherapy +17