The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

David W. Rusnak, Karen Lackey, Karen Affleck, +8

PubMed

PathologyCell ProliferationCell GrowthTumor BiologyOncology +14

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Nelson Rhodes, Dirk A. Heerding, Derek R. Duckett, +19

Cancer Research

Tumor XenograftsAntitumor ActivityChemoprevention StrategyApoptosisImmunology +19

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.

Brian J. Stevenson, Nelson Rhodes, Beverly Errede, +1

Genes & Development

Molecular RegulationGeneticsGenomic MechanismMolecular BiologyMolecular Genetics +21

Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study

Xue Ming, T. Peter Stein, Virginia Monsul Barnes, +2

Journal of Proteome Research

NutritionAsd ChildrenBiochemistryAutism Spectrum DisordersSyndromic Autism +10

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.

Nelson Rhodes, Laurie B. Connell, Beverly Errede

Genes & Development

Ste11 GeneGeneticsMolecular BiologyMolecular GeneticsCell Cycle +17

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3<i>S</i>)-3-piperidinylmethyl]oxy}-1<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Dirk A. Heerding, Nelson Rhodes, Jack D. Leber, +25

Journal of Medicinal Chemistry

Cell DeathAkt KinaseMolecular PharmacologyMedicinal ChemistryReceptor Tyrosine Kinase +18

Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.

Richard S. Paules, Eleni N. Levedakou, S J Wilson, +7

PubMed

Cancer PathologyG2 DelayCell DeathPathologyCancer Biology +17

Inflammation and Resolution Are Associated with Upregulation of Fatty Acid β-Oxidation in Zymosan-Induced Peritonitis

Yusuke Fujieda, Atsushi Manno, Yasuhiro Hayashi, +5

PLoS ONE

ImmunologyMetabolomic ProfilingPathologyOxidative StressInflammation +16

A yeast-Escherichia coli shuttle vector containing the M13 origin of replication

Nelson Rhodes

Plasmid

Natural SciencesMolecular BiologyDna ReplicationYeastMolecular Genetics +5

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

Nibedita Chattopadhyay, Allison Berger, Erik Koenig, +16

PLoS ONE

ImmunologyPathologyKras-wt Sw48 CellsCancer BiologyTumor Biology +15