A cellular census of human lungs identifies novel cell states in health and in asthma

Felipe A. Vieira Braga, Gozde Kar, Marijn Berg, +32

Nature Medicine

AsthmaHuman CellHuman Lungs IdentifiesCell StatesAllergy +10

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

David W. Rusnak, Karen Lackey, Karen Affleck, +8

PubMed

PathologyCell ProliferationCell GrowthTumor BiologyOncology +14

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

David W. Rusnak, Karen Affleck, Stuart Cockerill, +22

PubMed

Potential TherapyTumor BiologyOncologyDual Erbb-2/egfrReceptor Tyrosine Kinase +16

hCLCA1 and mCLCA3 Are Secreted Non-integral Membrane Proteins and Therefore Are Not Ion Channels

Adele Gibson, Alan P. Lewis, Karen Affleck, +3

Journal of Biological Chemistry

EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

Helmout Modjtahedi, Karen Affleck, Colin Stubberfield, +1

International Journal of Oncology

Tyrosine KinaseImmunologyImmunotherapyCancer BiologyTumor Biology +17

Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2

Stuart Cockerill, Colin Stubberfield, Jeremy N. Stables, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryIndazolylamino QuinazolinesMedicinePharmacological AgentPharmacotherapy +8

Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines

Micheal D. Gaul, Yu Guo, Karen Affleck, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignPharmacotherapyBiological Evaluation +5

Changes in LH pulse frequency and amplitude in intact mares during the transition into the breeding season

B. P. Fitzgerald, Karen Affleck, Susan Barrows, +3

Reproduction

FertilityGynecologyReproductive BiologyAbrupt Artificial IncreaseReproductive Endocrinology +16

Identification of asthma-associated microRNAs in bronchial biopsies

Mirjam P. Roffel, Ilse M. Boudewijn, Jos van Nijnatten, +10

European Respiratory Journal

Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission

Cornelis J. Vermeulen, Cheng‐Jian Xu, Judith M. Vonk, +10

European Respiratory Journal