Alastair Donald

Identification of 4-(4-Aminopiperidin-1-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration

John Caldwell, Thomas G. Davies, Alastair Donald et al. · Journal of Medicinal Chemistry · 2008 · 99 citations · Full text

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-<i>N</i>-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

David Moffat, Sanjay R. Patel, Francesca A. Day et al. · Journal of Medicinal Chemistry · 2010 · 82 citations · Full text

Drug Targeting to Monocytes and Macrophages Using Esterase-Sensitive Chemical Motifs

Lindsey Needham, Alan H. Davidson, Lindsay J. Bawden et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 68 citations

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design

Alastair Donald, Tatiana McHardy, Martin Rowlands et al. · Journal of Medicinal Chemistry · 2007 · 65 citations · Full text

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Ian Collins, John Caldwell, T. Faria Da Fonseca et al. · Bioorganic & Medicinal Chemistry · 2005 · 37 citations · Full text

Combinatorial Chemistry, Medicine, Rational Drug Design +4