Concepedia

Tatiana McHardy

TM

11

Publications

623

Citations

11

H-Index

2007

Active since

Affiliations

Institute of Cancer Research(Current)

Cancer Research UK

University of Leicester

Tatiana McHardy is an author at Institute of Cancer Research specializing in medicine, drug discovery, and pharmacology.

Top concepts

Publications per year

2007–2019

11

Publications

11

Identification of 4-(4-Aminopiperidin-1-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration

John Caldwell, Thomas G. Davies, Alastair Donald et al. · Journal of Medicinal Chemistry · 2008 · 99 citations · Full text

A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

Thomas G. Davies, Marcel L. Verdonk, Brent Graham et al. · Journal of Molecular Biology · 2007 · 89 citations · Full text

, , +11

Discovery of 4-Amino-1-(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

Tatiana McHardy, John Caldwell, Kwai-Ming J. Cheung et al. · Journal of Medicinal Chemistry · 2010 · 83 citations · Full text

, , +17

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

Mike I. Walton, Paul D. Eve, Angela Hayes et al. · Oncotarget · 2015 · 68 citations · Full text

, , +19

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design

Alastair Donald, Tatiana McHardy, Martin Rowlands et al. · Journal of Medicinal Chemistry · 2007 · 65 citations · Full text

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