Brent Graham

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 258 citations

Pharmaceutical Science, Novel Inhibitor, Drug Target +19

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 185 citations · Full text

Molecular Docking, High Ligand Efficiency, Medicinal Chemistry +15

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

S. Saalau-Bethell, Andrew Woodhead, Gianni Chessari et al. · Nature Chemical Biology · 2012 · 111 citations · Full text

Virus Structure, Viral Replication, Signal Transduction +8

A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

Thomas G. Davies, Marcel L. Verdonk, Brent Graham et al. · Journal of Molecular Biology · 2007 · 89 citations · Full text

Biochemistry, Pka-pkb Chimera, Natural Sciences +11

The heat shock protein 90 inhibitor, <scp>AT</scp>13387, displays a long duration of action <i>in vitro</i> and <i>in vivo</i> in non‐small cell lung cancer

Brent Graham, Jayne Curry, Tomoko Smyth et al. · Cancer Science · 2011 · 80 citations · Full text

Tumor Xenografts, Chemoprevention Strategy, Molecular Biology +17