Gordon Saxty

Identification of <i>N</i>-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1<i>H</i>-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Paul G. Wyatt, Andrew Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2008 · 337 citations · Full text

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Timothy Perera, Eleonora Jovcheva, Laurence Mévellec et al. · Molecular Cancer Therapeutics · 2017 · 335 citations · Full text

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 295 citations · Full text

Molecular Biology, Chemical Biology, Redox Biology +19

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

Gordon Saxty, Steven J. Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2007 · 138 citations · Full text

Molecular Docking, Medicinal Chemistry, Drug Target +14

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Tom D. Heightman, James F. Callahan, Elisabetta Chiarparin et al. · Journal of Medicinal Chemistry · 2019 · 91 citations · Full text