Joseph E. Coyle

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Barbara Chaneton, Petra Hillmann, Liang Zheng et al. · Nature · 2012 · 665 citations

Life Sciences, Biochemistry, Molecular Biology +9

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 306 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 263 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 186 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure of GABARAP in Two Conformations

Joseph E. Coyle, Seema Qamar, Kanagalaghatta R. Rajashankar et al. · Neuron · 2002 · 145 citations · Full text

Natural Sciences, Biochemistry, Biophysics +10