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Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP

Raphaëlle Pardossi‐Piquard, Agnès Petit-Paitel, Toshitaka Kawarai, Claire Sunyach, Cristine Alvès da Costa, Bruno Vincent, Sabine Ring, Luciano D'adamio, Ulrike Müller, Peter St George‐Hyslop,

Neuron · 2005 · 334 citations · 48 references

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48

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

, , +15

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

, , +15

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

Debra Burdick, Brian Soreghan, Min‐Sung Kwon et al. · Journal of Biological Chemistry · 1992 · 998 citations · Full text

, , +17