Wesley Farris

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 701 citations · Full text

Premature Death, Neurodegenerative Diseases, Enhanced Proteolysis +11

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Wesley Farris, Stefan Mansourian, Malcolm A. Leissring et al. · American Journal Of Pathology · 2004 · 260 citations · Full text

Induce Diabetes, Biochemistry, Protein Folding +10

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

Malcolm A. Leissring, Wesley Farris, Xining Wu et al. · Biochemical Journal · 2004 · 159 citations · Full text

Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy

Wesley Farris, Sonja G. Schütz, John R. Cirrito et al. · American Journal Of Pathology · 2007 · 151 citations · Full text

Alzheimer's Disease, Neurochemical Biomarkers, Neuroprotection +7