Malcolm A. Leissring

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 708 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

Malcolm A. Leissring, Yama Akbari, Christopher M. Fanger et al. · The Journal of Cell Biology · 2000 · 332 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Zeshan Ahmed, Ya-Fei Xu, Wen-Lang Lin et al. · American Journal Of Pathology · 2010 · 306 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Malcolm A. Leissring, M. Paul Murphy, Tonya R. Mead et al. · Proceedings of the National Academy of Sciences · 2002 · 266 citations · Full text

Life Sciences, Cell Biology, Neuroscience +16

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Wesley Farris, Stefan Mansourian, Malcolm A. Leissring et al. · American Journal Of Pathology · 2004 · 264 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16