Malcolm A. Leissring

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 701 citations · Full text

Premature Death, Neurodegenerative Diseases, Enhanced Proteolysis +11

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

Malcolm A. Leissring, Yama Akbari, Christopher M. Fanger et al. · The Journal of Cell Biology · 2000 · 331 citations · Full text

Calcium Signaling, Cellular Physiology, Alzheimer's Disease +16

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Zeshan Ahmed, Sheng Hong, Ya-Fei Xu et al. · American Journal Of Pathology · 2010 · 299 citations · Full text

Inflammation, Lifespan Extension, Successful Aging +8

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Malcolm A. Leissring, M. Paul Murphy, Tonya R. Mead et al. · Proceedings of the National Academy of Sciences · 2002 · 266 citations · Full text

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Wesley Farris, Stefan Mansourian, Malcolm A. Leissring et al. · American Journal Of Pathology · 2004 · 260 citations · Full text

Induce Diabetes, Biochemistry, Protein Folding +10