Concepedia

Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators

Tomoharu Iino, Daisuke Tsukahara, Kenji Kamata, Kaori Sasaki, Sumika Ohyama, Hideka Hosaka, Takuro Hasegawa, Masato Chiba, Yasufumi Nagata, Jun‐ichi Eiki,

Bioorganic & Medicinal Chemistry · 2009 · 66 citations · 8 references

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References

8

Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett et al. · Science · 2003 · 537 citations

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Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura et al. · Structure · 2004 · 503 citations · Full text

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An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism

Mayumi Futamura, Hideka Hosaka, Akito Kadotani et al. · Journal of Biological Chemistry · 2006 · 101 citations · Full text

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Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 85 citations · Full text

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Glucokinase activators as new type 2 diabetes therapeutic agents

Ramakanth Sarabu, Steven J. Berthel, Robert F. Kester et al. · Expert Opinion on Therapeutic Patents · 2008 · 59 citations

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