An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism

Mayumi Futamura, Hideka Hosaka, Akito Kadotani, +6

Journal of Biological Chemistry

Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators

Tomoharu Iino, Daisuke Tsukahara, Kenji Kamata, +8

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryActive 3-Alkoxy-5-phenoxy-n-thiazolyl BenzamidesMedicine +6

Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass

Akinobu Nakamura, Yasuo Terauchi, Sumika Ohyama, +9

Endocrinology

NutritionBeta Cell ProliferationGlucose ToleranceInsulin SignalingMetabolic Syndrome +17

Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators

Makoto Ishikawa, Katsumasa Nonoshita, Yoshio Ogino, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryNatural SciencesMedicineDrug Development +5

Structure–activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy

Tomoharu Iino, Noriaki Hashimoto, Kaori Sasaki, +8

Bioorganic & Medicinal Chemistry

Molecular PharmacologyPharmaceutical Science3,5-Disubstituted BenzamidesBiochemistryMedicine +8

Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators

Morihiro Mitsuya, Kenji Kamata, Makoto Bamba, +8

Bioorganic & Medicinal Chemistry Letters

Derivative (Chemistry)MedicineOrganic ChemistryPharmacologyChemical Derivative +2

Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators

T. Nishimura, Tomoharu Iino, Morihiro Mitsuya, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineAllosteric Glucokinase ActivatorsNatural Sciences +6

Continuous Exposure to a Novel Stressor Based on Water Aversion Induces Abnormal Circadian Locomotor Rhythms and Sleep-Wake Cycles in Mice

Koyomi Miyazaki, Nanako Itoh, Sumika Ohyama, +2

PLoS ONE

Sleep DisordersHomeostatic MechanismLocomotor ActivitySocial SciencesSleep-wake Cycles +21

Discovery and structure–activity relationships of a novel class of quinazoline glucokinase activators

Tomoharu Iino, Yasuhiro Sasaki, Makoto Bamba, +14

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesQuinazoline Glucokinase ActivatorsNovel Class +7

Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs

Jun‐ichi Eiki, Yasufumi Nagata, Mayumi Futamura, +14

Molecular Pharmacology