Concepedia

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett, Craig S. Donald, Mark L. Fenwick, Emma Grange, Keith M. Johnson, Craig Johnstone, Clifford D. Jones, Kurt G. Pike,

Bioorganic & Medicinal Chemistry Letters · 2006 · 85 citations · 9 references

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9

Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett et al. · Science · 2003 · 537 citations

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Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura et al. · Structure · 2004 · 503 citations · Full text

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A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Alexander M. Efanov, David G. Barrett, Martin Brenner et al. · Endocrinology · 2005 · 132 citations · Full text

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Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

Katy J. Brocklehurst, Victoria A. Payne, Rick A. Davies et al. · Diabetes · 2004 · 130 citations · Full text

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Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young

Anna L. Gloyn, Stella Odili, Dorothy Zelent et al. · Journal of Biological Chemistry · 2005 · 108 citations · Full text

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