Clifford D. Jones

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

Laura Hewitt, Anthony Tighe, Stefano Santaguida et al. · The Journal of Cell Biology · 2010 · 333 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 85 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +6

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 78 citations · Full text

Medicine, Oncology, Pharmacology +17

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Jack Exell, Mark J. Thompson, L. David Finger et al. · Nature Chemical Biology · 2016 · 77 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +5