Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura, +2

Structure

Allosteric RegulationBiochemistryNatural SciencesMolecular BiologyEnzyme Specificity +3

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

Gentaroh Suzuki, Naohiro Tsukamoto, Hiroshi Fushiki, +6

Journal of Pharmacology and Experimental Therapeutics

Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors

Yoshiyuki Satô, Yu Onozaki, T Sugimoto, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesReceptor Tyrosine Kinase +9

J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors

Morihiro Mitsuya, Toshiaki Mase, Yoshimi Tsuchiya, +10

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityMedicinePhysiologyMechanism Of Action +6

A Potent, Long-Acting, Orally Active (2<i>R</i>)-2-[(1<i>R</i>)-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide:  A Novel Muscarinic M₃ Receptor Antagonist with High Selectivity for M₃ over M₂ Receptors

Morihiro Mitsuya, Kensuke Kobayashi, Kumiko Kawakami, +11

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryBiochemistryFunctional Selectivity +13

Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators

Morihiro Mitsuya, Kenji Kamata, Makoto Bamba, +8

Bioorganic & Medicinal Chemistry Letters

Derivative (Chemistry)MedicineOrganic ChemistryPharmacologyChemical Derivative +2

Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators

T. Nishimura, Tomoharu Iino, Morihiro Mitsuya, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineAllosteric Glucokinase ActivatorsNatural Sciences +6

Discovery and structure–activity relationships of a novel class of quinazoline glucokinase activators

Tomoharu Iino, Yasuhiro Sasaki, Makoto Bamba, +14

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesQuinazoline Glucokinase ActivatorsNovel Class +7

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists

Masayuki Nakamura, Hideki Kurihara, Gentaroh Suzuki, +3

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineIsoxazolopyridone DerivativesMechanism Of Action +6

Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129

Morihiro Mitsuya, Kumiko Kawakami, Yoshio Ogino, +2

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +6