Concepedia

Structure-based Allosteric Design

Structure-Based Allosteric Design is a computational and theoretical framework within allosteric drug design that leverages high-resolution three-dimensional structures of biomolecules to identify and engineer allosteric sites and modulators through precise spatial and energetic characterization of protein conformations and inter-residue interactions.

56

Publications

2.6K

Citations

500

Authors

131

Institutions

Publications per year

2017–2026

25

Parents

Publications

56

Light-activated DNA binding in a designed allosteric protein

Devin Strickland, Keith Moffat, Tobin R. Sosnick · Proceedings of the National Academy of Sciences · 2008 · 310 citations · Full text

, , +16

Computational design and experimental validation of oligonucleotide-sensing allosteric ribozymes

Robert Penchovsky, Ronald R. Breaker · Nature Biotechnology · 2005 · 213 citations

, , +16

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

John D. McCorvy, Kyle V. Butler, Brendan Kelly et al. · Nature Chemical Biology · 2017 · 177 citations · Full text

, , +16

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

Hao Shao, Xiaokai Li, Michael A. Moses et al. · Journal of Medicinal Chemistry · 2018 · 120 citations · Full text

, , +14

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons et al. · Nature · 2024 · 102 citations

, , +16

1–5 of 56

Authors

500

  1. GK
    George Kukolj

    Boehringer Ingelheim (Canada), Canada

    3 publications · 79 citations

    3

    h-index

  2. IN
    Igor N. Berezovsky

    Bioinformatics Institute, Singapore

    3 publications · 91 citations

    3

    h-index

  3. MP
    Martin Poirier

    Boehringer Ingelheim (Canada), Canada

    3 publications · 79 citations

    3

    h-index

  4. WT
    Wei-Ven Tee

    Bioinformatics Institute, Singapore

    3 publications · 91 citations

    3

    h-index

  5. PL
    Pierre L. Beaulieu

    Boehringer Ingelheim (Canada), Canada

    3 publications · 79 citations

    3

    h-index

1–5 of 500

Institutions

131

  1. National University of Singapore

    Singapore, Singapore

    3 h-index

    3 publications

    91 citations

  2. Boehringer Ingelheim (Canada)

    Burlington, Canada

    3 h-index

    40 publications

    1.1K citations

  3. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    7 publications

    235 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    323 citations

  5. Agency for Science, Technology and Research

    Singapore, Singapore

    3 h-index

    10 publications

    280 citations

  6. Bioinformatics Institute

    Singapore, Singapore

    3 h-index

    10 publications

    280 citations

  7. University of California, San Francisco

    San Francisco, United States

    3 h-index

    15 publications

    1.6K citations

  8. Peking University

    Beijing, China

    2 h-index

    2 publications

    109 citations

1–8 of 131

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    10 publications · 325 citations

    10

    h-index

  2. Journal of Medicinal Chemistry

    8 publications · 372 citations

    9

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 471 citations

    4

    h-index

  4. Bioorganic & Medicinal Chemistry

    3 publications · 129 citations

    3

    h-index

  5. Archives of Biochemistry and Biophysics

    ABB · 2 publications · 31 citations

    2

    h-index

1–5