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Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

DOI

70

Citations

35

References

2005

Year

Luigi Quintieri, Cristina Geroni, Marianna Fantin, R. Battaglia, Antonio Rosato, William C. Speed, Paola Zanovello, Maura Floreani
Clinical Cancer Research

Abstract

CYP3A4, the major CYP in human liver, converts MMDX to a more cytotoxic metabolite, PNU-159682, which retains antitumor activity in vivo.

References

YearCitations

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