Concepedia

Rat Liver Microsomes

Rat Liver Microsomes is a subcellular fraction derived from rat hepatocytes that contains endoplasmic reticulum fragments and drug-metabolizing enzymes, particularly cytochrome P450 isoforms, used in vitro to assess the metabolic stability and biotransformation potential of xenobiotics.

11.5K

Publications

572.9K

Citations

26.1K

Authors

3.2K

Institutions

Publications per year

2017–2026

389

Parents

Publications

11.5K

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

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The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 3.5K citations · Full text

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Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences · 1990 · 3.3K citations

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AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

Gian Luigi Sottocasa, Bo Kuylenstierna, Lars Ernster et al. · The Journal of Cell Biology · 1967 · 2.3K citations · Full text

, , +17

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

Yukio Fujiki, A L Hubbard, S Fowler et al. · The Journal of Cell Biology · 1982 · 1.8K citations · Full text

, , +15

1–5 of 11.5K

Authors

26.1K

  1. WL
    Wayne Levin

    La Roche College, United States

    110 publications · 9.8K citations

    57

    h-index

  2. FP
    F. Peter Guengerich

    Vanderbilt University, United States

    77 publications · 9.2K citations

    52

    h-index

  3. DE
    Dene E. Ryan

    La Roche College, United States

    52 publications · 5.8K citations

    37

    h-index

  4. CS
    Chung S. Yang

    Rutgers, The State University of New Jersey, United States

    49 publications · 3.8K citations

    37

    h-index

  5. MI
    Magnus Ingelman‐Sundberg

    Karolinska Institutet, Sweden

    48 publications · 3.8K citations

    36

    h-index

1–5 of 26.1K

Institutions

3.2K

  1. Karolinska Institutet

    Stockholm, Sweden

    69 h-index

    657 publications

    39.6K citations

  2. National Institutes of Health

    Bethesda, United States

    66 h-index

    633 publications

    45.7K citations

  3. Vanderbilt University

    Nashville, United States

    49 h-index

    303 publications

    23.3K citations

  4. University of Wisconsin–Madison

    Madison, United States

    48 h-index

    275 publications

    15.6K citations

  5. University of Michigan

    Ann Arbor, United States

    47 h-index

    266 publications

    27.6K citations

  6. La Roche College

    Pittsburgh, United States

    46 h-index

    276 publications

    29.3K citations

  7. Rutgers, The State University of New Jersey

    New Brunswick, United States

    42 h-index

    287 publications

    17K citations

  8. The University of Osaka

    Osaka, Japan

    41 h-index

    219 publications

    47.3K citations

1–8 of 3.2K

Venues

  1. Journal of Biological Chemistry

    JBC · 751 publications · 86.3K citations

    133

    h-index

  2. PubMed

    Repository · 740 publications · 33.8K citations

    87

    h-index

  3. Drug Metabolism and Disposition

    643 publications · 29.5K citations

    79

    h-index

  4. Archives of Biochemistry and Biophysics

    ABB · 340 publications · 20.4K citations

    76

    h-index

  5. European Journal of Biochemistry

    EJB · 242 publications · 14.5K citations

    71

    h-index

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