Concepedia

Enzymatic Bioactivation

Enzymatic Bioactivation is the metabolic process by which an inactive bioprecursor prodrug is selectively converted into its pharmacologically active form through catalytic transformation by specific enzymes.

176

Publications

7K

Citations

730

Authors

220

Institutions

Publications per year

2017–2026

21

Parents

Publications

176

Lysostaphin: Enzymatic mode of action

Henry P. Browder, Walter A. Zygmunt, Jungmo Young et al. · Biochemical and Biophysical Research Communications · 1965 · 232 citations

, , +8

Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator

James P. Quigley · Cell · 1979 · 167 citations

, , +14

Genetic Variations in Human Glutathione Transferase Enzymes: Significance for Pharmacology and Toxicology

P. David Josephy · Human Genomics and Proteomics · 2010 · 158 citations · Full text

, , +14

Specific and Irreversible Inactivation of Pepsin by Substrate-like Epoxides

Jordan Tang · Journal of Biological Chemistry · 1971 · 148 citations · Full text

, , +16

SATURATION TOXICOKINETICS OF THIOACETAMIDE: ROLE IN INITIATION OF LIVER INJURY

Jaya Chilakapati · Drug Metabolism and Disposition · 2005 · 148 citations

, , +17

1–5 of 176

Authors

730

  1. PG
    Peter G. Wells

    University of Toronto, Canada

    6 publications · 219 citations

    6

    h-index

  2. JE
    John E. Casida

    University of California, Berkeley, United States

    5 publications · 211 citations

    5

    h-index

  3. XD
    Xinxin Ding

    New York State Department of Health, United States

    4 publications · 165 citations

    4

    h-index

  4. DP
    Dimitri Petsikas

    Queen's University, Canada

    3 publications · 96 citations

    3

    h-index

  5. KR
    Ken R. Reid

    Queen's University, Canada

    3 publications · 96 citations

    3

    h-index

1–5 of 730

Institutions

220

  1. University of Toronto

    Toronto, Canada

    8 h-index

    27 publications

    828 citations

  2. University of California, Berkeley

    Berkeley, United States

    5 h-index

    13 publications

    541 citations

  3. Pfizer (United States)

    New York, United States

    5 h-index

    15 publications

    811 citations

  4. University of Minnesota

    Minneapolis, United States

    5 h-index

    15 publications

    403 citations

  5. University of Liverpool

    Liverpool, United Kingdom

    5 h-index

    23 publications

    707 citations

  6. Daiichi-Sankyo (Japan)

    Tokyo, Japan

    4 h-index

    6 publications

    171 citations

  7. University of Washington

    Seattle, United States

    4 h-index

    13 publications

    231 citations

  8. National University of Singapore

    Singapore, Singapore

    4 h-index

    21 publications

    334 citations

1–8 of 220

Venues

  1. Chemical Research in Toxicology

    27 publications · 1K citations

    19

    h-index

  2. Drug Metabolism and Disposition

    23 publications · 871 citations

    17

    h-index

  3. PubMed

    Repository · 6 publications · 445 citations

    6

    h-index

  4. Xenobiotica

    6 publications · 119 citations

    6

    h-index

  5. 6

    h-index

1–5