Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune, +3

Journal of Biological Chemistry

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

Linda M. Distlerath, P.E.B. Reilly, M V Martin, +3

Journal of Biological Chemistry

Expression of Modified Human Cytochrome P450 1A2 in Escherichia coli: Stabilization, Purification, Spectral Characterization, and Catalytic Activities of the Enzyme

Punam Sandhu, Zhimou Guo, T. Baba, +3

Archives of Biochemistry and Biophysics

BiochemistryNatural SciencesEnzyme CatalysisCatalytic ActivitiesMolecular Biology +5

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

Jorge H. Capdevila, Armando Karara, David J. Waxman, +3

Journal of Biological Chemistry

Metabolomic ProfilingMicrosomal EpoxygenaseChemical BiologyRedox BiologyOxidative Stress +16

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.

T. Wolff, Linda M. Distlerath, Mark Worthington, +6

PubMed

Metabolomic ProfilingImmunochemical InhibitionToxicological MechanismAflatoxin B1Bioanalysis +17

Expression of Cytochrome P450 2D6 in Escherichia coli, Purification, and Spectral and Catalytic Characterization

Elizabeth M. J. Gillam, Zhimou Guo, M V Martin, +2

Archives of Biochemistry and Biophysics

BiochemistryNatural SciencesBiochemical GeneticsEscherichia ColiMolecular Biology +4

Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.

John R. Falck, Sun Lumin, Ian A. Blair, +5

Journal of Biological Chemistry

Lipid PeroxidationMetabolomic ProfilingCytochrome P-450-dependent OxidationRedox BiologyOxidative Stress +16

Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation

F. Peter Guengerich, Linda M. Distlerath, P.E.B. Reilly, +4

Xenobiotica

In situ localization and distribution of xenobiotic-activating enzymes and aryl hydrocarbon hydroxylase activity in lungs of untreated rats.

Jeffrey M. Voigt, Thomas T. Kawabata, Jon P. Burke, +3

Molecular Pharmacology

Polymorphism of human cytochrome P-450

F. Peter Guengerich, Diane R. Umbenhauer, Perry F. Churchill, +5

Xenobiotica