Concepedia

Oxidative Bioactivation

Oxidative Bioactivation is a metabolic activation mechanism within the bioprecursor prodrug paradigm wherein enzymatic oxidation transforms an inactive precursor into its pharmacologically active form through the introduction of oxygen atoms or formation of reactive intermediates.

117

Publications

6.3K

Citations

511

Authors

142

Institutions

Publications per year

2017–2026

8

Parents

Publications

117

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

Stephen J. Weiss, Gary J. Peppin, X. Ortiz et al. · Science · 1985 · 469 citations

, , +17

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

Richard M. Burger, J. Peisach, Susan Band Horwitz · Journal of Biological Chemistry · 1981 · 464 citations · Full text

, , +9

Metabolism and Toxicity of Thioacetamide and Thioacetamide <i>S</i>-Oxide in Rat Hepatocytes

Heather Hajovsky, Gang Hu, Yakov M. Koen et al. · Chemical Research in Toxicology · 2012 · 197 citations

, , +17

Oxidative Stress and Mitochondrial Aldehyde Dehydrogenase Activity: A Comparison of Pentaerythritol Tetranitrate with Other Organic Nitrates

Andreas Daiber, Matthias Oelze, Meike Coldewey et al. · Molecular Pharmacology · 2004 · 176 citations

, , +9

Genetic Variations in Human Glutathione Transferase Enzymes: Significance for Pharmacology and Toxicology

P. David Josephy · Human Genomics and Proteomics · 2010 · 158 citations · Full text

, , +14

1–5 of 117

Authors

511

  1. JE
    John E. Casida

    University of California, Berkeley, United States

    5 publications · 211 citations

    5

    h-index

  2. WG
    W. Griffith Humphreys

    Bristol-Myers Squibb (United States), United States

    5 publications · 201 citations

    5

    h-index

  3. PG
    Peter G. Wells

    University of Toronto, Canada

    5 publications · 294 citations

    5

    h-index

  4. NV
    Nico Vermeulen

    Vrije Universiteit Amsterdam, Netherlands

    4 publications · 143 citations

    4

    h-index

  5. JN
    Jan N. M. Commandeur

    Vrije Universiteit Amsterdam, Netherlands

    4 publications · 143 citations

    4

    h-index

1–5 of 511

Institutions

142

  1. University of Toronto

    Toronto, Canada

    7 h-index

    18 publications

    754 citations

  2. University of Liverpool

    Liverpool, United Kingdom

    6 h-index

    34 publications

    1.2K citations

  3. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    29 publications

    1.1K citations

  4. University of California, Berkeley

    Berkeley, United States

    5 h-index

    13 publications

    541 citations

  5. University of Minnesota

    Minneapolis, United States

    4 h-index

    16 publications

    660 citations

  6. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    4 h-index

    22 publications

    747 citations

  7. University of Michigan

    Ann Arbor, United States

    4 h-index

    11 publications

    2.5K citations

  8. Pfizer (United States)

    New York, United States

    4 h-index

    8 publications

    261 citations

1–8 of 142

Venues

  1. Chemical Research in Toxicology

    28 publications · 1.3K citations

    20

    h-index

  2. Drug Metabolism and Disposition

    12 publications · 442 citations

    12

    h-index

  3. 4

    h-index

  4. Xenobiotica

    4 publications · 72 citations

    4

    h-index

  5. Molecular Pharmacology

    4 publications · 363 citations

    4

    h-index

1–5