Concepedia

3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats

Andrew S. Felts, Stacey R. Lindsley, Jeffrey P. Lamb, Alice L. Rodriguez, Usha N. Menon, Satyawan Jadhav, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte

Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · 42 references

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42

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Cristiano Chiamulera, Mark P. Epping-Jordan, Alessandro Zocchi et al. · Nature Neuroscience · 2001 · 549 citations

, , +14

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP

Qijiang Yan, Mustapha Rammal, Michael R. Tranfaglia et al. · Neuropharmacology · 2005 · 525 citations

, , +5

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

Elizabeth Berry‐Kravis, David Hessl, Sarah M. Coffey et al. · Journal of Medical Genetics · 2009 · 410 citations · Full text

, , +13

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

, , +16