Lonazolac analogues: molecular modeling, synthesis, and in vivo anti-inflammatory activity

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

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Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

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Design and Synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors:  Replacement of Sulfonamide and Methylsulfonyl Pharmacophores by an Azido Bioisostere

Amgad G. Habeeb, Praveen P. N. Rao, Edward E. Knaus · Journal of Medicinal Chemistry · 2001 · 219 citations · Full text

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Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore Models

Albert Palomer, Francesc Cabré, Jaume Pascual et al. · Journal of Medicinal Chemistry · 2002 · 205 citations · Full text

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