Eculizumab therapy for atypical haemolytic uraemic syndrome due to a gain-of-function mutation of complement factor B

Atypical hemolytic uremic syndrome

Chantal Loirat, Véronique Frémeaux‐Bacchi · Orphanet Journal of Rare Diseases · 2011 · 664 citations · Full text

Medicine, Hematology, Nephrology +17

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome

Elena Goicoechea de Jorge, Claire L. Harris, Jorge Esparza-Gordillo et al. · Proceedings of the National Academy of Sciences · 2006 · 445 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome

Tara Maga, Carla Nishimura, Amy E. Weaver et al. · Human Mutation · 2010 · 309 citations · Full text

Life Sciences, Genetics, Hematology +16

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

Fredrik Bexborn, Per Ola Andersson, Hui Chen et al. · Molecular Immunology · 2007 · 152 citations · Full text

Life Sciences, Biochemistry, Immunology +10

Eculizumab induces long-term remission in recurrent post-transplant HUS associated with C3 gene mutation

Samhar Al‐Akash, P. Stephen Almond, Salam Gharaybeh et al. · Pediatric Nephrology · 2010 · 95 citations

Life Sciences, Clinical Sciences, Immunology +7